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Cold sores. They can be embarrassing, uncomfortable and all too often, unpredictable. Feel the tingle of an oncoming outbreak and you can feel the anxiety begin. How long will it last? Will it still be here when I have my party (or meeting, or date or vacation)?

Denavir® (penciclovir cream, 1%) can help you take control. Because Denavir is a cream, you apply it directly to your cold sore. And the healing can begin.4

Be ready. Having prescription Denavir on hand means you can be ready when you first feel a cold sore coming on.

Denavir helps you go from “hide” to “hi”. It:

  • Helps cold sores go away faster. And the pain, too.† Denavir targets the virus that causes cold sores,‡ reducing the duration of the cold sore and the duration of the pain it may cause.4,5
  • Relieves discomfort. Denavir is a topical cream that reduces discomfort from dryness and cracking.2
  • Works at the tingle or the blister. Denavir starts working from the time you feel the tingle.4 And unlike some other prescription and over-the-counter cold sore medicines, Denavir can be started when the blister forms.4 (Learn how to use Denavir.)
  • Dries clear and is steroid-free. Non-greasy Denavir goes on smooth and dries clear. And it doesn’t contain steroids.4
  • Well-tolerated. The most common side effect with Denavir was headache, which occurred in 5.3% of patients treated with Denavir and 5.8% of those who received a cream that contained no medication (placebo).4 (Learn more about Denavir side effects.)

† Compared with placebo treatment.
‡ Denavir selectively targets cells infected with HSV-1 and prevents the virus from reproducing.


Expand Safety Information

Denavir® (penciclovir cream, 1%) is indicated for the treatment of recurrent herpes labialis
(cold sores) in adults and children 12 years of age and older.

Important Safety Information

Denavir should only be used on herpes labialis on the lips or face. Application to mucous membranes is not recommended. Denavir should not be used in patients with known hypersensitivity to the product or any of its ingredients.

There are no adequate and well-controlled Denavir studies in pregnant women; therefore, Denavir should be used during pregnancy only if clearly needed. There is no information on whether Denavir is excreted in human milk after topical administration; a decision whether to discontinue Denavir should take into account the importance of the drug to the mother. The effect of Denavir has not been established in immunocompromised patients. Denavir does not cure cold sores.

In clinical studies, the most common adverse reaction with Denavir was headache, which occurred in 5.3% of patients who received Denavir and 5.8% of patients who received placebo. Other adverse reactions with Denavir occurred in less than 2% of patients and included application site reaction, decreased sensitivity to touch/local anesthesia, taste perversion, and rash.

Other reported adverse reactions have included swelling of the mouth or throat, pain, alterations in sense of smell, abnormal touch sensation, itching, skin discoloration, and hives.

Denavir is available by prescription only. Please see the Full Prescribing Information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call
1-800-FDA-1088.